10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 1 Development of Complex Curricula for Molecular Bionics and Infobionics Programs within a consortial* framework** Consortium leader PETER PAZMANY CATHOLIC UNIVERSITY Consortium members SEMMELWEIS UNIVERSITY, DIALOG CAMPUS PUBLISHER The Project has been realised with the support of the European Union and has been co-financed by the European Social Fund *** **Molekuláris bionika és Infobionika Szakok tananyagának komplex fejlesztése konzorciumi keretben ***A projekt az Európai Unió támogatásával, az Európai Szociális Alap társfinanszírozásával valósul meg. PETER PAZMANY CATHOLIC UNIVERSITY SEMMELWEIS UNIVERSITY sote_logo.jpg dk_fejlec.gif INFOBLOKK 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 2 Peter Pazmany Catholic University Faculty of Information Technology BEVEZETÉS A FUNKCIONÁLIS NEUROBIOLÓGIÁBA INTRODUCTION TO FUNCTIONAL NEUROBIOLOGY THE NEUROENDOCRINE HYPOTHALAMUS www.itk.ppke.hu (A neuroendokrin hypothalamus) ZSOLT LIPOSITS INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 3 www.itk.ppke.hu midsagbrain xxxx Hypothalamo-hypophyseal regulation Limbic system INTRODUCTION TO FUNCTIONAL NEUROBIOLOGY The neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 4 www.itk.ppke.hu Hypothalamo-pituitaryunit 1endopic INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 5 www.itk.ppke.hu HPG-system HPT-system HPA-system HPP-system Endocrine pancreas Reproduction Metabolism Adaptation Water, salt balance Carbohydrate metabolism Sterility Graves disease Addison disease Diabetes insipidus Diabetes mellitus Significanceof the endocrine system MILIEU INTERIEUR INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 6 www.itk.ppke.hu HYPOTHALAMUS P P AP REPRODUCTION STRESS, ADAPTATION GROWTH FEEDING ENERGY EXPENDITURE THERMOREGULATION WATER AND SALT BALANCE MILK EJECTION SEXUAL BEHAVIOR BRAIN STEM SPINAL CORD AUTONOMIC NERVOUS SYSTEM REGULATION OF VISCERAL FUNCTIONS TARGET ORGANS HOMEOSTASIS HYPOTHALAMUS P P AP REPRODUCTION STRESS, ADAPTATION GROWTH FEEDING ENERGY EXPENDITURE THERMOREGULATION WATER AND SALT BALANCE MILK EJECTION SEXUAL BEHAVIOR BRAIN STEM SPINAL CORD AUTONOMIC NERVOUS SYSTEM REGULATION OF VISCERAL FUNCTIONS TARGET ORGANS HOMEOSTASIS INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 7 www.itk.ppke.hu pitparts pitcircul NEUROSECRETION pituitary-hyp anim_nerve CONSTITUENTS,BLOOD SUPPLY,NEUROSECRETION INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 www.itk.ppke.hu portalves HYPOTHALAMO-HYPOPHYSEAL UNIT HYPOTHALAMUS A ADENOHYPOPHYSIS SHA PV NEUROHYPOPHYSIS STALK N E U R A L V A S C U L A R INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 9 www.itk.ppke.hu PORTAL VEINS TO ADENOHYPOPHYSIS DISSEMINATION OF RELEASING AND RELEASE-INHIBITING HORMONES TO HYPOPHYSEAL TROPH CELLS PORTAL CAPILLARIES FROM SUPERIOR HYPOPHYSEAL ARTERY DISCHARGE OF HYPOTHALAMIC RELEASING AND RELEASE-INHIBITING NEUROSECRETORY HORMONES INTO PORTAL CIRCULATION DISCHARGE OF HYPOPHYSEAL TROPH HORMONES AP PP MAGNOCELLULAR parvicellular INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 10 www.itk.ppke.hu pitintermed AP PP PI INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 11 www.itk.ppke.hu HYPOPHYSEAL HORMONES INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 12 PITUITARY G.Harris A.Schally J.Szentágothai B.Halász M.Palkovits O B.Flerkó POA W.Bargmann E.Scharrer A. Schally, R. Guillemin, W. Vale, J. Rivier INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 13 www.itk.ppke.hu glandcysthyperFB parvicellsystSZJ Halászknife PÉCS From: Szentágothai, J., Flerkó, B., Mess, B., Halász, B., : Hypothalamic Control of the Anterior Pituitary, Akadémiai Kiadó, Budapest, 1962 INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 14 www.itk.ppke.hu brainsagtol Anterior Rat Thalamus POA SCN DM VM ARC CM PVN brainventrsurf CHO LH PG PS ME INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 15 www.itk.ppke.hu OVLT O V L T CA OCH GONAD REGULATION THERMOREGULATION CORTICAL ACTIVATION SEXUAL BEHAVIOUR INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 16 www.itk.ppke.hu OVLT2 M P O A SEXUAL BEHAVIOUR MATERNAL BEHAVIOUR GONAD REGULATION THERMOREGULATION INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 17 www.itk.ppke.hu PVN P V N ADRENAL REGULATION THYROID REGULATION METABOLISM ADAPTATION AUTONOMIC REGULATION GROWTH INHIBITION WATER BALANCE ELECTROLYTE BALANCE MILK EJECTION UTERUS CONTRACTION INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 18 www.itk.ppke.hu DM-VM DM VM ARCLH ME GROWTH REGULATION FEEDING REGULATION SEXUAL BEHAVIOUR INHIBITION OF LACTATION HORMONE DISCHARGE INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 19 www.itk.ppke.hu TM MB TM LEARNING-MEMORY SLEEP REGULATION INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 20 www.itk.ppke.hu MAGNOCELLULAR SYSTEM PVN ANTERIOR POSTERIORSUBNUCLEI SON ACCESSORY INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 21 www.itk.ppke.hu PVNtol3 III. pc MC INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 22 www.itk.ppke.hu PVNparvoempl MC INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 23 www.itk.ppke.hu Thalamus OCH PVN SON PL PS PSHT oxytsem AVPsem Magnoimmun INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 24 www.itk.ppke.hu Vasopressin (antidiuretic hormone, ADH) Blood vessels: vasoconstriction via V1a receptors Anteriorpituitary: ACTH release via V1breceptors Kidney: sodium and water reabsorption via V2receptors Brain: neuromodulation Oxytocin Lactating breast: milk ejection Uterus: smooth muscle contraction Brain: neuromodulation INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 25 www.itk.ppke.hu PARVICELLULAR SYSTEM INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 26 www.itk.ppke.hu PVNparce P V N INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 27 www.itk.ppke.hu PVNEM INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 28 www.itk.ppke.hu PVNneurop INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 29 www.itk.ppke.hu Median eminence Ependymal Hypependymal Internal External Basement membrane INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 30 www.itk.ppke.hu Median eminence MEem INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 31 www.itk.ppke.hu PS INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 32 www.itk.ppke.hu CRHaxem C R H INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 33 www.itk.ppke.hu Hypothalamic neurosecretory hormones 1. Synthesized in neurons 2. Transported via axo-plasmic flow 3. Stored and released from axon terminals 4. Secreted into the blood stream 5. Have specific receptors 6. Influence target structures via receptor-coupled mechanisms 7. Biologically active INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 34 www.itk.ppke.hu Retrograde labellingof neurosecretory cells FGretr FLUORO-GOLD labelling Hypophysiotrophic somatostain neurons INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 35 www.itk.ppke.hu Nu rer mRNA ISHH protein ICC SOMFG CRHmRNA INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 36 www.itk.ppke.hu hypofizhorsem INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 37 www.itk.ppke.hu Luteinizing hormone-releasing hormone (LHRH) Thyrotropin-releasing hormone (TRH) Somatostatin Corticotropin-releasing hormone (CRH) Growth hormone-releasing hormone (GHRH) Dopamine Oxytocin Vasopressin Neurophysin I-II Galanin CART INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 38 www.itk.ppke.hu Thalamus OCH pv Medial preoptic area Paraventricular nucleus Periventricular nucleus Arcuate nucleus Supraoptic nucleus INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 39 www.itk.ppke.hu Thalamus OCH LHRHcells LHRHnyél MPOA ME LHRHsem LHRH INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 40 www.itk.ppke.hu parvicelneuron3 34 30 Pulsatile secretion of GnRH and LH Positive estrogen trigger GnRH and LH peaks induced by estrogen INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 41 www.itk.ppke.hu LHRHrendszsem INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 42 www.itk.ppke.hu LHRH neurons in the OVLT region of the rat lhrhg lhrhr LHRH GAL INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 43 www.itk.ppke.hu Thalamus OCH PV SOMsema SOMFG SOM INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 44 www.itk.ppke.hu CRHlmem PVNXCRH PVNX CRH PVN-X INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 45 www.itk.ppke.hu Thalamus OCH PVN TRHsem PVNtrh TRH INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 46 www.itk.ppke.hu Thalamus OCH GHRHsema CRH,GHRH3TIF ARC GH-RH INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 47 www.itk.ppke.hu SOM GHRH SOM-GHRH INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 48 www.itk.ppke.hu C1-3proj CRHpnmtlm PNMT-CRH INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 49 www.itk.ppke.hu Brain H P Target organs A T G Endocrine organs HORMONAL FEEDBACK ACTIONS GR CRH 1987 INTRODUCTION TO FUNCTIONAL NEUROBIOLOGYThe neuroendocrine hypothalamus 10/15/2011. TÁMOP –4.1.2-08/2/A/KMR-2009-0006 50 www.itk.ppke.hu